Harry A. Pollard (Director)
Margarita Fischer
Eliza
James B. Lowe
Uncle Tom
Arthur Edmund Carewe
George Harris
George Siegmann
Simon Legree
Eulalie Jensen
Cassy
Mona Ray
Topsy
Virginia Grey
Evangeline 'Eva' St. Clare
Lassie Lou Ahern
Little Harry
Lucien Littlefield
Lawyer Marks
Adolph Milar
Mr. Haley
J. Gordon Russell
Loker
Gertrude Howard
Aunt Chloe
Jack Mower
Mr. Shelby
Vivien Oakland
Mrs. Shelby
John Roche
Augustine St. Claire
Aileen Manning
Aunt Ophelia
Gertrude Astor
Mrs. St. Clare (uncredited)
Francis Ford
Captain (uncredited)
Rolfe Sedan
Adolph (uncredited)
Dick Sutherland
Sambo (uncredited)
Nelson McDowell
Phineas Fletcher (uncredited)
Rondo Hatton
Slave (uncredited)
C.E. Anderson
Johnson (uncredited)
Carla Laemmle
Auction Spectator (uncredited)
Jeanette Loff
Auction Spectator (uncredited)
Madame Sul-Te-Wan
Slave at Wedding (uncredited)
Clarence Wilson
Bidder at Eliza's Auction (uncredited)
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In 1856, slave Eliza plans to marry George with the consent of the Shelbys, her masters, but George's owner prevents the wedding. A few years later, Eliza flees with her son, Harry, after learning the Shelbys plan to hand them over to a crooked creditor to prevent foreclosure. George also escapes and goes on the run while Eliza and Harry are captured and brought back home. Mother and son are separated as George tries to find them both.
