Gary Cooper

Henry Louis 'Lou' Gehrig

Teresa Wright

Eleanor Twitchell

Babe Ruth

Babe Ruth

Walter Brennan

Sam Blake

Dan Duryea

Hank Hanneman

Elsa Janssen

Christina 'Mom' Gehrig

Ludwig Stössel

Henry 'Pop' Gehrig

Virginia Gilmore

Myra Tinsley

Bill Dickey

Bill Dickey

Ernie Adams

Miller Huggins

Pierre Watkin

Mr. Twitchell

Harry Harvey

Joe McCarthy

Bob Meusel

Robert W. Meusel (as Robert W. Meusel)

Mark Koenig

Mark Koenig

Bill Stern

Bill Stern

Addison Richards

Coach

Hardie Albright

Van Tuyl

Edward Fielding

Clinic Doctor

George Lessey

Mayor of New Rochelle

Edgar Barrier

Hospital Doctor

Douglas Croft

Lou Gehrig as a Boy

Gene Collins

Billy (Age 8)

David Holt

Billy (Age 17)

Veloz

Specialty Dancer (as Veloz and Yolanda)

Yolanda

Specialty Dancer (as Veloz and Yolanda)

Ed Agresti

Barber (uncredited)

Ernie Alexander

Bellhop with Flowers (uncredited)

Hooper Atchley

Lathered Man in Barber Shop (uncredited)

Edwin August

Restaurant Patron (uncredited)

Bettye Avery

Nightclub Singer (uncredited)

Becky Bohanon

Little Girl (uncredited)

Lynton Brent

Photographer in Hospital (uncredited)

Roy Brent

Yankee Ballplayer (uncredited)

Betty Brewer

Little Girl (uncredited)

Don Brodie

Girl Show Barker (uncredited)

Charles Cane

Plumber (uncredited)

Jack Carr

Plumber (uncredited)

Burr Caruth

Village Storekeeper (uncredited)

Eddy Chandler

Motorcycle Cop #2 (uncredited)

Lane Chandler

Mark - Player in Locker Room (uncredited)