Ellen Burstyn

Sara Goldfarb

Jared Leto

Harry Goldfarb

Jennifer Connelly

Marion Silver

Marlon Wayans

Tyrone C. Love

Christopher McDonald

Tappy Tibbons

Louise Lasser

Ada

Marcia Jean Kurtz

Rae

Janet Sarno

Mrs. Pearlman

Suzanne Shepherd

Mrs. Scarlini

Joanne Gordon

Mrs. Ovadia

Charlotte Aronofsky

Mrs. Miles

Mark Margolis

Mr. Rabinowitz

Michael Kaycheck

Donut Cop

Jack A. O'Connell

Corn Dog Stand Boss

Chas Mastin

Lyle Russel

Ajay Naidu

Mailman

Sean Gullette

Arnold the Shrink

Samia Shoaib

Nurse Mall

Peter Maloney

Dr. Pill

Abraham Abraham

King Neptune

Aliya Campbell

Alice

Te'ron A. O'Neal

Young Tyrone

Denise Dowse

Tyrone's Mother

Bryan Chattoo

Brody

Eddie De Harp

Brody's Henchman Victor

Scott Franklin

Jailer (voice)

Peter Cheyenne

Sal the Geep

Brian Costello

First AD

Abraham Aronofsky

Newspaper Man on Train

James Chinlund

Space Oddity

Olga Merediz

Malin & Block Secretary

Allison Furman

Malin & Block Office Woman

Robert Dylan Cohen

Paramedic Greenhill

Ben Shenkman

Dr. Spencer

Keith David

Big Tim

Dylan Baker

Southern Doctor

Shaun O'Hagan

Ward Attendant Seto

Leland Gantt

Ward Attendant Penn

Bill Buell

Court Doctor

Jimmie Ray Weeks

Prison Guard